张蠑：这是一篇重要文献。 脑内的Oxytocin和vasopressin参与调节与人际关系有关的行为。 > 脑内这两种神经肽功能不足可能是导致孤独症的原因之一。 > 针刺使其含量增高，当有助于该病的治疗。 > 韩济生 10/08/2007 - > Effect of oxytocin on acupuncture analgesia in the rat. > Country: China > Institute: Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin > Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529080, China. > Author(s): Yang J, Yang Y, Chen JM, Liu WY, Wang CH, Lin BC. > Journal: 1: Neuropeptides. 2007 Jul 28; > Abstract: > Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture an > algesia is a very useful clinical tool for pain relief, which has over 2500-year > history in China. The present study investigated the role of oxytocin in acupun > cture analgesia in the rat through oxytocin administration and measurement. > Central administration of oxytocin (intraventricular injection or intrathecal in > jection) enhanced acupuncture analgesia, while central administration of anti-ox > ytocin serum weakened acupuncture analgesia in a dose-dependent manner. However, > intravenous injection of oxytocin or anti-oxytocin serum did not influence acup > uncture analgesia. Electrical acupuncture of "Zusanli" (St. 36) reduced oxytocin > concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin con > centration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedia > l nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, > caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter > oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pit > uitary, posterior pituitary and plasma. > The data suggested that oxytocin in central nervous system rather than in periph > eral organs is involved in acupuncture analgesia. > > > > > > Han，Ji-Sheng, MD > Director, Neuroscience Resarch Institute > Peking University